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Article

Critical role of IL-10 in the induction of low zone tolerance to contact allergens

1 Aug 2003

Abstract excerpt

The development and mechanisms of tolerance to allergens are poorly understood. Using the murine low zone tolerance (LZT) model, where contact hypersensitivity (CHS) is prevented by repeated topical low-dose applications of contact allergens, we show that LZT induction is IL-10 dependent. IL-10 is required for the generation of LZT effector cells, that is, CD8+ regulatory T cells. Only T cells from tolerized...

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PMID: 12865418
DOI: 10.1172/jci18106

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