Article
Distinct role of p38 and c-Jun N-terminal kinases in IL-10-dependent and IL-10-independent regulation of the costimulatory molecule B7.2 in lipopolysaccharide-stimulated human monocytic cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2002
Lim Wilfred, Ma Wei, Gee Katrina, Aucoin Susan, Nandan Devki, Diaz-Mitoma Francisco, Kozlowski Maya, Kumar Ashok
Abstract excerpt
The costimulatory molecule B7.2 (CD86) plays a vital role in immune activation and development of Th responses. The molecular mechanisms by which B7.2 expression is regulated are not understood. We investigated the role of mitogen-activated protein kinases (MAPK) in the regulation of B7.2 expression in LPS-stimulated human monocytic cells. LPS stimulation of human monocytes resulted in the down-regulation of B7.2...
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