Article
Impact of growth factors in the regulation of apoptosis in low-risk myelodysplastic syndromes.
Medical oncology (Northwood, London, England) - 1 Jan 2006
Tehranchi R
Abstract excerpt
Increased apoptosis of hematopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe anemia observed in the low-risk subgroups, refractory anemia (RA) and RA with ringed sideroblasts (RARS). Treatment with erythropoietin (Epo) alone or in combination with granulocyte...
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