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Article

Genetic variants of TSLP and asthma in an admixed urban population.

PloS one - 1 Jan 2011

Liu Mengling, Rogers Linda, Cheng Qinyi, Shao Yongzhao, Fernandez-Beros Maria Elena, Hirschhorn Joel N, Lyon Helen N, Gajdos Zofia K Z, Vedantam Sailaja, Gregersen Peter, Seldin Michael F, Bleck Bertram, Ramasamy Adaikalavan, Hartikainen Anna-Liisa, Jarvelin Marjo-Riitta, Kuokkanen Mikko, Laitinen Tarja, Eriksson Johan, Lehtimäki Terho, Raitakari Olli T, Reibman Joan

Abstract excerpt

BACKGROUND: Thymic stromal lymphopoietin (TSLP), an IL7-like cytokine produced by bronchial epithelial cells is upregulated in asthma and induces dendritic cell maturation supporting a Th2 response. Environmental pollutants, including tobacco smoke and diesel exhaust particles upregulate TSLP suggesting that TSLP may be an interface between environmental pollution and immune responses in asthma. Since asthma is...

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Source

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Identifiers

PMID: 21966427
DOI: 10.1371/journal.pone.0025099
PMCID: PMC3178593

Genes

TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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