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Article

The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.

PloS one - 21 Oct 2010

Wan Taib Wan R, Smyth Deborah J, Merriman Marilyn E, Dalbeth Nicola, Gow Peter J, Harrison Andrew A, Highton John, Jones Peter B B, Stamp Lisa, Steer Sophia, Todd John A, Merriman Tony R

Abstract excerpt

OBJECTIVES: The Trp(620) allotype of PTPN22 confers susceptibility to rheumatoid arthritis (RA) and certain other classical autoimmune diseases. There has been a report of other variants within the PTPN22 locus that alter risk of RA; protective haplotype '5', haplotype group '6-10' and susceptibi...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 20975833
DOI: 10.1371/journal.pone.0013544
PMCID: PMC2958827

Genes

PTPN22
BCL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20975833-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.PMID 20975833Read ↗

Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.Semantic proximity Read ↗

Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK.Semantic proximity Read ↗

PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): Updated systematic review and meta-analysis.Semantic proximity Read ↗

Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.Semantic proximity Read ↗

Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.Semantic proximity Read ↗

PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.Semantic proximity Read ↗

Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.Semantic proximity Read ↗

The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.Semantic proximity Read ↗

The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.Semantic proximity Read ↗

Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.Semantic proximity Read ↗

PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.Semantic proximity Read ↗

1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis.Semantic proximity Read ↗

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