The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.

doi:10.1038/sj.gene.6364159

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Article

The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.

Genes and immunity - 1 Mar 2005

Lee A T, Li W, Liew A, Bombardier C, Weisman M, Massarotti E M, Kent J, Wolfe F, Begovich A B, Gregersen P K

Abstract excerpt

We have recently described the association between rheumatoid arthritis and a coding single-nucleotide polymorphism in the intracellular protein tyrosine phosphatase, PTPN22. The disease-associated polymorphism, 1858 C/T (rs2476601), encodes an amino-acid change (R620W) in one of four SH3 domain binding sites in the PTPN22 molecule. We have now extended our initial studies to address three questions: (1) Is the...

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PMID: 15674368
DOI: 10.1038/sj.gene.6364159

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PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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