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Article

Liver organogenesis promoted by endothelial cells prior to vascular function.

Science (New York, N.Y.) - 19 Oct 2001

Matsumoto K, Yoshitomi H, Rossant J, Zaret K S

Abstract excerpt

The embryonic role of endothelial cells and nascent vessels in promoting organogenesis, prior to vascular function, is unclear. We find that early endothelial cells in mouse embryos surround newly specified hepatic endoderm and delimit the mesenchymal domain into which the liver bud grows. In flk-1 mutant embryos, which lack endothelial cells, hepatic specification occurs, but liver morphogenesis fails prior to...

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PMID: 11577199
DOI: 10.1126/science.1063889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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