Article
Genetic regulation of branching morphogenesis: lessons learned from loss-of-function phenotypes.
Pediatric research - 1 Oct 2003
Hu Ming Chang, Rosenblum Norman D
Abstract excerpt
Branching morphogenesis, defined as growth and branching of epithelial tubules during embryogenesis, is a fundamental feature of renal, lung, mammary gland, submandibular gland, and pancreatic morphogenesis in mammals. Disruption of branching morphogenesis has been demonstrated to result in maldevelopment of some of these organs. Genetic studies performed in affected humans and mutant mice have implicated...
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