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Article

A DNA replication enhancer in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990

Walker S S, Francesconi S C, Eisenberg S

Abstract excerpt

We have dissected the autonomously replicating sequence ARS121 using site-directed in vitro mutagenesis. Three domains important for origin function were identified; one of these is essential and contains an 11-base-pair sequence resembling the canonical ARS core consensus; the second region, deletion of which affects the efficiency of the origin, is located 3' to the T-rich strand of the essential sequence and...

Topics

Base Sequence
Chromosome Deletion
DNA Replication
DNA, Fungal
Enhancer Elements, Genetic
Escherichia coli
Molecular Sequence Data
Mutation
Plasmids
Restriction Mapping
Saccharomyces cerevisiae

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Identifiers

PMID: 2191298
DOI: 10.1073/pnas.87.12.4665
PMCID: PMC54177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2191298-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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