Article
Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner.
Journal of virology - 1 Aug 1990
Schmidt A, Hennighausen L, Siebenlist U
Abstract excerpt
Cyclosporin A (CsA) is thought to exert its immunosuppressive effects by inhibiting the expression of a distinct set of lymphokine genes which are induced upon T-cell activation, among them the gene coding for interleukin-2. In addition, the activation of the human immunodeficiency virus (HIV) is...
Topics
- Base Sequence
- Cell Line
- Cell Nucleus
- Cyclosporins
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- HIV
- Humans
- Interleukin-2
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Oligonucleotide Probes
- Signal Transduction
- T-Lymphocytes
- Tetradecanoylphorbol Acetate
- Transcription Factors