Article
Interaction between Cell Cycle Regulator, E2F-1, and NF-κB Mediates Repression of HIV-1 Gene Transcription
1 Nov 1997
Abstract excerpt
The NF-kappaB/Rel family of transcription factors is one of the main targets of cytokines and other agents that induce HIV-1 gene expression. Some of these extracellular stimuli arrest cells in the G1 phase of the mitotic division cycle and modulate the activity of the tumor suppressor protein Rb and its partner E2F-1. Earlier studies indicated that E2F-1, a transcription factor that stimulates expression of...
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