Article
Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element.
The Journal of biological chemistry - 5 Aug 1991
Verweij C L, Geerts M, Aarden L A
Abstract excerpt
Production of interleukin-2 (IL-2) by human T-lymphocytes can be augmented by costimulation via CD28. It has been reported that signaling via CD28 acts by stabilization of lymphokine mRNAs (Lindsten, T., June, C. H., Ledbetter, J. A., Stella, G., and Thompson, C. B. (1989) Science 244, 339-343)....
Topics
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- CD28 Antigens
- Chloramphenicol O-Acetyltransferase
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Humans
- Interleukin-2
- Lymphoma, T-Cell
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Promoter Regions, Genetic
- Tetradecanoylphorbol Acetate
- Transcription, Genetic
- Transfection
- Tumor Cells, Cultured