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Article

Comparison of high-resolution melting analysis, Sanger sequencing and ARMS for KRAS mutation detection in metastatic colorectal cancer.

Clinical laboratory - 1 Jan 2015

Zhang Haiyan, Zhang Xiaoming, Wang Jie, Xian Jiang, Chen Xiaodong, Zhang Wei

Abstract excerpt

BACKGROUND: Treatment of metastatic colon carcinoma with the anti-epidermal growth factor receptor antibody cetuximab/panitumumab is reported to be ineffective in KRAS-mutant tumors; therefore, it is necessary to perform KRAS mutation analysis before cetuximab or panitumumab treatment is initiated. METHODS: This study was designed to compare and evaluate the efficacy of three different methodologies--high...

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Identifiers

PMID: 25975014
DOI: 10.7754/clin.lab.2014.140923

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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