Article
Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety.
Psychiatric genetics - 1 Aug 2011
Molina Esther, Cervilla Jorge, Rivera Margarita, Torres Francisco, Bellón Juan Angel, Moreno Berta, King Michael, Nazareth Irwin, Gutiérrez Blanca
Abstract excerpt
BACKGROUND: Serotonin 1-A receptors are key regulators of serotonin activity and their dysregulation might be implicated in the emergence of both major depression (MD) and generalized anxiety disorder (GAD). Previous studies have yielded inconclusive results as to whether the 5-HT1A receptor gene (HTR1A) has a role in the aetiology of MD and no study up to date has analysed this polymorphism on either pure MD or...
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