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Article

Isolation and characterization of the CYP2D6 gene in Felidae with comparison to other mammals.

Journal of molecular evolution - 1 Feb 2011

Schenekar Tamara, Winkler Kathrin A, Troyer Jennifer L, Weiss Steven

Abstract excerpt

The highly polymorphic CYP2D6 protein metabolizes about 25% of commonly used drugs and underlies a broad spectrum of drug responses among individuals. In contrast to extensive knowledge on the human CYP2D6 gene, little is known about the gene in non-human mammals. CYP2D6 mRNA from 23 cats (Felidae) spanning seven species were compared to available CYPD6 sequences in ten additional mammals and multiple allelic...

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PMID: 21188366
DOI: 10.1007/s00239-010-9424-1

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