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Article

Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2014

Uno Yasuhiro, Uehara Shotaro, Kohara Sakae, Murayama Norie, Yamazaki Hiroshi

Abstract excerpt

Cynomolgus macaques and rhesus macaques are nonhuman primate species widely used in drug metabolism studies. Cynomolgus CYP2D17, highly homologous to human CYP2D6, metabolizes human CYP2D6 substrates such as bufuralol and dextromethorphan, and the gene is expressed predominantly in liver. Although human CYP2D6 variants account for the variability of the enzyme properties among individuals and populations, genetic...

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PMID: 24985704
DOI: 10.1124/dmd.114.059220

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