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Discovery of genetic variants in CYP1D1: implication for functional integrity of CYP1D1 in cynomolgus macaques and rhesus macaques.

Drug metabolism and pharmacokinetics - 1 Jan 2011

Uno Yasuhiro, Uehara Shotaro, Yamazaki Hiroshi

Abstract excerpt

The cytochrome P450 (CYP) 1 family consists of the CYP1A, CYP1B, CYP1C, and CYP1D subfamilies. In humans, CYP1A1, CYP1A2, and CYP1B1 are expressed and encode functional enzymes, whereas CYP1D1P (formerly known as CYP1A8P) is present as a pseudogene as a result of five nonsense mutations in exon 2 and exon 7 of the putative coding region. We previously identified CYP1D1 in macaques and found that it was expressed...

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PMID: 21844658
DOI: 10.2133/dmpk.DMPK-11-NT-026

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