Impact of EGFR genetic variants on glioma risk and patient outcome.

doi:10.1158/1055-9965.EPI-11-0340

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Article

Impact of EGFR genetic variants on glioma risk and patient outcome.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2011

Costa Bruno Marques, Viana-Pereira Marta, Fernandes Ricardo, Costa Sandra, Linhares Paulo, Vaz Rui, Pinheiro Céline, Lima Jorge, Soares Paula, Silva Ana, Pardal Fernando, Amorim Júlia, Nabiço Rui, Almeida Rui, Alegria Carlos, Pires Manuel Melo, Pinheiro Célia, Carvalho Ernesto, Oliveira Pedro, Lopes José M, Reis Rui M

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the...

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PMID: 21960689
DOI: 10.1158/1055-9965.EPI-11-0340

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EGFR
IMPACT

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