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Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Jan 2012

Assefa Netsanet Gizaw, Niiranen Laila, Willassen Nils Peder, Smalås Arne, Moe Elin

Abstract excerpt

Uracil-DNA N-glycosylase (UNG; EC 3.2.2.27) from Atlantic cod (cUNG) possesses cold adapted features like increased catalytic efficiency and reduced temperature optimum for activity compared to its warm-adapted homologue human UNG (hUNG). Here, we present the first thermal stability analysis of cUNG and hUNG by differential scanning calorimetry (DSC), and the results showed that cUNG is less stable than hUNG and...

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Identifiers

PMID: 21959147
DOI: 10.1016/j.cbpb.2011.09.007

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UNG

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