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Article

Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1.

The Journal of biological chemistry - 11 Feb 2011

Zhou Huina, Brock Joseph, Casarotto Marco G, Oakley Aaron J, Board Philip G

Abstract excerpt

The polymorphic deletion of Glu-155 from human glutathione transferase omega1 (GSTO1-1) occurs in most populations. Although the recombinant ΔGlu-155 enzyme expressed in Escherichia coli is active, the deletion causes a deficiency of the active enzyme in vivo. The crystal structure and the folding/unfolding kinetics of the ΔGlu-155 variant were determined in order to investigate the cause of the rapid loss of the...

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Identifiers

PMID: 21106529
DOI: 10.1074/jbc.M110.197822
PMCID: PMC3039386

Genes

GSTO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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