Article
Highly site-selective stability increases by glycosylation of dihydrofolate reductase.
The FEBS journal - 1 May 2010
Tey Lai-Hock, Loveridge E Joel, Swanwick Richard S, Flitsch Sabine L, Allemann Rudolf K
Abstract excerpt
Post-translational glycosylation is one of the most abundant forms of covalent protein modification in eukaryotic cells. It plays an important role in determining the properties of proteins, and stabilizes many proteins against thermal denaturation. Protein glycosylation may establish a surface microenvironment that resembles that of unglycosylated proteins in concentrated solutions of sugars and other polyols....
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