Article
Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua).
Journal of molecular biology - 5 Nov 2004
Moe Elin, Leiros Ingar, Riise Ellen Kristin, Olufsen Magne, Lanes Olav, Smalås Arneo, Willassen Nils Peder
Abstract excerpt
Cold-adapted enzymes are characterised by an increased catalytic efficiency and reduced temperature stability compared to their mesophilic counterparts. Lately, it has been suggested that an optimisation of the electrostatic surface potential is a strategy for cold adaptation for some enzymes. A visualisation of the electrostatic surface potential of cold-adapted uracil-DNA N-glycosylase (cUNG) from Atlantic cod...
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