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Article

Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.

Journal of Huntington's disease - 1 Oct 2016

Vodicka Petr, Chase Kathryn, Iuliano Maria, Tousley Adelaide, Valentine Dana T, Sapp Ellen, Kegel-Gleason Kimberly B, Sena-Esteves Miguel, Aronin Neil, DiFiglia Marian

Abstract excerpt

BACKGROUND: Mutant huntingtin (mHTT) is encoded by the Huntington's disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulates lysosome biogenesis and autophagy. OBJECTIVE: To examine if increasing TFEB protein levels in HD mouse striatum...

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Topics

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27689619
DOI: 10.3233/JHD-160211
PMCID: PMC5088406

Genes

TFEB
GFAP
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.PMID 27689619Read ↗

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