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Stem cell-derived polarized hepatocytes

3 Apr 2020

Abstract excerpt

Human stem cell-derived hepatocyte-like cells (HLCs) offer an attractive platform to study liver biology. Despite their numerous advantages, HLCs lack critical in vivo characteristics, including cell polarity. Here, we report a stem cell differentiation protocol that uses transwell filters to generate columnar polarized HLCs with clearly defined basolateral and apical membranes separated by tight junctions. We...

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PMID: 32245952
DOI: 10.1038/s41467-020-15337-2

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