Article
Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.
International journal of obesity (2005) - 1 Oct 2010
Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Döring A, Rückert I M, Hinney A, Hebebrand J, Wichmann H-E, Hauner H, Illig T, Heid I M
Abstract excerpt
BACKGROUND: Data from meta-analyses of genome-wide association studies provided evidence for an association of polymorphisms with body mass index (BMI), and gene expression results indicated a role of these variants in the hypothalamus. It was consecutively hypothesized that these associations might be evoked by a modulation of nutritional intake or energy expenditure. OBJECTIVE: It was our aim to investigate the...
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