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Article

A-type lamins: guardians of the soma?

Nature cell biology - 1 Nov 2004

Hutchison Chris J, Worman Howard J

Abstract excerpt

The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of transcription factors required for the differentiation of adult stem cells. Thus, the...

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Source

Identifiers

PMID: 15517000
DOI: 10.1038/ncb1104-1062

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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