Article
Neuromuscular transmission and muscle contractility in SNAP-25-deficient coloboma mice.
Neurotoxicology - 1 Dec 2001
Adler M, Sheridan R E, Deshpande S S, Oyler G A
Abstract excerpt
Synaptosomal associated protein of 25 kDa (SNAP-25) is a cytoplasmic protein that participates in the docking and fusion of synaptic vesicles with the nerve terminal in preparation for neurotransmitter release. SNAP-25 is also a substrate for three of the seven serotypes of botulinum neurotoxin (BoNT). Intoxication by BoNT/A, /C1 or /E results in weakness and paralysis of skeletal muscle due to cleavage of...
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