Article
Toward more accurate pan-specific MHC-peptide binding prediction: a review of current methods and tools.
Briefings in bioinformatics - 1 May 2012
Zhang Lianming, Udaka Keiko, Mamitsuka Hiroshi, Zhu Shanfeng
Abstract excerpt
Binding of short antigenic peptides to major histocompatibility complex (MHC) molecules is a core step in adaptive immune response. Precise identification of MHC-restricted peptides is of great significance for understanding the mechanism of immune response and promoting the discovery of immunogenic epitopes. However, due to the extremely high MHC polymorphism and huge cost of biochemical experiments, there is no...
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