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Article

Dissecting electrostatic interactions in Bacillus circulans xylanase through NMR-monitored pH titrations.

Journal of biomolecular NMR - 1 Sept 2011

McIntosh Lawrence P, Naito Daigo, Baturin Simon J, Okon Mark, Joshi Manish D, Nielsen Jens E

Abstract excerpt

NMR-monitored pH titration curves of proteins provide a rich source of structural and electrostatic information. Although relatively straightforward to measure, interpreting pH-dependent chemical shift changes to obtain site-specific acid dissociation constants (pK (A) values) is challenging. In order to analyze the biphasic titrations exhibited by the side chain (13)C(γ) nuclei of the...

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PMID: 21947911
DOI: 10.1007/s10858-011-9537-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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