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Article

pK(a) values for side-chain carboxyl groups of a PGB1 variant explain salt and pH-dependent stability.

Biophysical journal - 1 Jan 2007

Lindman Stina, Linse Sara, Mulder Frans A A, André Ingemar

Abstract excerpt

Determination of pK(a) values of titrating residues in proteins provides a direct means of studying electrostatic coupling as well as pH-dependent stability. The B1 domain of protein G provides an excellent model system for such investigations. In this work, we analyze the observed pK(a) values of all carboxyl groups in a variant of PGB1 (T2Q, N8D, N37D) at low and high ionic strength as determined using...

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Identifiers

PMID: 17040982
DOI: 10.1529/biophysj.106.088682
PMCID: PMC1697841

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