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Article

Charge Interactions in a Highly Charge-Depleted Protein.

Journal of the American Chemical Society - 17 Feb 2021

Hervø-Hansen Stefan, Højgaard Casper, Johansson Kristoffer Enøe, Wang Yong, Wahni Khadija, Young David, Messens Joris, Teilum Kaare, Lindorff-Larsen Kresten, Winther Jakob Rahr

Abstract excerpt

Electrostatic forces are important for protein folding and are favored targets of protein engineering. However, interactions between charged residues are difficult to study because of the complex network of interactions found in most proteins. We have designed a purposely simple system to investigate this problem by systematically introducing individual and pairs of charged and titratable residues in a protein...

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Identifiers

PMID: 33529004
DOI: 10.1021/jacs.0c10789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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