Article
A pteridine derivative with electron-withdrawing groups for binding and sensing of nucleobases in AP site-containing DNA duplexes.
Nucleic acids symposium series (2004) - 1 Jan 2008
Kanai Eriko, Nishizawa Seiichi, Teramae Norio
Abstract excerpt
A pteridine derivative having electron-withdrawing CF(3) groups, 2-amino-6,7-bis(trifluoromethyl)-4-hydoroxypteridine (2CF(3)-pteridine), is presented as a candidate for multi-functional fluorescent ligand for single-nucleotide polymorphisms (SNPs) typing. In solutions buffered to pH 8.0 (I = 0.1 M, at 5 degrees C), 2CF(3)- pteridine can bind to guanine, cytosine and thymine opposite an abasic site in DNA...
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