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Article

Hopelessness, a potential endophenotpye for suicidal behavior, is influenced by TPH2 gene variants.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2012

Lazary Judit, Viczena Veronika, Dome Peter, Chase Diana, Juhasz Gabriella, Bagdy Gyorgy

Abstract excerpt

OBJECTIVES: Hopelessness is one of the strongest risk factors for suicidal behavior but relevant genetic studies are poorly available. Tryptophan hydroxylase (TPH) is widely considered to be a good candidate for genetic association studies on depression and suicide, however, investigations on these complex, multifactorial phenotypes have resulted in conflicting data. We hypothesized that hopelessness could be a...

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Source

Identifiers

PMID: 21946031
DOI: 10.1016/j.pnpbp.2011.09.001

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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