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Article

Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study.

Journal of general internal medicine - 1 Oct 2010

Kangelaris Kirsten Neudoerffer, Vittinghoff Eric, Otte Christian, Na Beeya, Auerbach Andrew D, Whooley Mary A

Abstract excerpt

BACKGROUND: Hopelessness is associated with mortality in patients with cardiac disease even after accounting for severity of depression. We sought to determine whether a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with increased hopelessness, and whether this effect is modified by sex, age, antidepressant use or depression in patients with coronary heart disease....

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Identifiers

PMID: 20509052
DOI: 10.1007/s11606-010-1403-0
PMCID: PMC2955461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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