Article
EGFR and KRAS mutations detection on lung cancer liquid-based cytology: a pilot study.
Journal of clinical pathology - 1 Jan 2012
Malapelle Umberto, de Rosa Nicla, Rocco Danilo, Bellevicine Claudio, Crispino Carlo, Illiano Alfonso, Piantedosi Franco Vito, Nappi Oscar, Troncone Giancarlo
Abstract excerpt
In advanced non-small-cell lung carcinomas epidermal growth factor receptor (EGFR) and KRAS testing is often performed on cytology. Liquid-based cytology (LBC), which eliminates the need for slide preparation by clinicians, may be very useful. In 42 LBC DNA was extracted twice. One sample was obtained directly from CytoLyt solution, whereas the other DNA sample was derived after smear preparation and laser...
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