Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Avian-Type Receptor-Binding Ability Can Increase Influenza Virus Pathogenicity in Macaques

22 Sept 2011

Abstract excerpt

The first influenza pandemic of the 21st century was caused by novel H1N1 viruses that emerged in early 2009. An Asp-to-Gly change at position 222 of the receptor-binding protein hemagglutinin (HA) correlates with more-severe infections in humans. The amino acid at position 222 of HA contributes to receptor-binding specificity with Asp (typically found in human influenza viruses) and Gly (typically found in avian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Influenza Virus Research Studies
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21937653
DOI: 10.1128/jvi.00859-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Avian-Type Receptor-Binding Ability Can Increase Influenza Virus Pathogenicity in MacaquesPMID 21937653Read ↗

Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K.Semantic proximity Read ↗

Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus.Semantic proximity Read ↗

A single-amino-acid substitution in the HA protein changes the replication and pathogenicity of the 2009 pandemic A (H1N1) influenza viruses in vitro and in vivoSemantic proximity Read ↗

An avian influenza H5N1 virus that binds to a human-type receptor.Semantic proximity Read ↗

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.Semantic proximity Read ↗

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity.Semantic proximity Read ↗

A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human‐type receptorsSemantic proximity Read ↗

Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza virusesSemantic proximity Read ↗

The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptorsSemantic proximity Read ↗

The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets.Semantic proximity Read ↗

Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor BindingSemantic proximity Read ↗

Structural basis for receptor specificity of influenza B virus hemagglutininSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.