Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBP

15 Sept 2011

Abstract excerpt

The androgen receptor (AR) has a central role in development and maintenance of the male reproductive system and in the etiology of prostate cancer. The transcription factor Pax6 has recently been reported to act as a repressor of AR and to be hypermethylated in prostate cancer cells. SPBP is a transcriptional regulator that previously has been shown to enhance the activity of Pax6. In this study we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21935435
DOI: 10.1371/journal.pone.0024659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pax6 Represses Androgen Receptor-Mediated Transactivation by Inhibiting Recruitment of the Coactivator SPBPPMID 21935435Read ↗

Androgen Receptor (AR) Coregulators: An OverviewSemantic proximity Read ↗

The chromatin remodeling factor SRCAP modulates expression of prostate specific antigen and cellular proliferation in prostate cancer cellsSemantic proximity Read ↗

Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT.Semantic proximity Read ↗

A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progressionSemantic proximity Read ↗

The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variantsSemantic proximity Read ↗

Foxa1 and Foxa2 Interact with the Androgen Receptor to Regulate Prostate and Epididymal Genes DifferentiallySemantic proximity Read ↗

Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1.Semantic proximity Read ↗

Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Factor CHD8Semantic proximity Read ↗

Repressors of Androgen and Progesterone Receptor ActionSemantic proximity Read ↗

Targeting SP1 Transcription Factor in Prostate Cancer TherapySemantic proximity Read ↗

Global Genome Analysis of the Downstream Binding Targets of Testis Determining Factor SRY and SOX9Semantic proximity Read ↗

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.