Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2002

Holter Elin, Kotaja Noora, Mäkela Sari, Strauss Leena, Kietz Silke, Jänne Olli A, Gustafsson Jan-Ake, Palvimo Jorma J, Treuter Eckardt

Abstract excerpt

DAX-1 (NROB1) is an atypical member of the nuclear receptor family that is predominantly expressed in mammalian reproductive tissues. While a receptor function of DAX-1 remains enigmatic, previous work has indicated that DAX-1 inhibits the activity of the orphan receptor steroidogenic factor 1 and the estrogen receptors (ERs), presumably via direct occupation of the coactivator-binding surface and subsequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Steroidogenic Factor 1
Share to Androgen Receptor Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DAX-1 Orphan Nuclear Receptor

Share to Fluorescent Antibody Technique, Indirect

Share to Immunosorbent Techniques

Share to Receptors, Retinoic Acid

Share to Response Elements

Share to TATA Box

Source

Identifiers

PMID: 11875111
DOI: 10.1210/mend.16.3.0804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1.PMID 11875111Read ↗

DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual DifferentiationSemantic proximity Read ↗

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA.Semantic proximity Read ↗

Repressors of Androgen and Progesterone Receptor ActionSemantic proximity Read ↗

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Semantic proximity Read ↗

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization.Semantic proximity Read ↗

Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.Semantic proximity Read ↗

DAX1: Increasing complexity in the roles of this novel nuclear receptor.Semantic proximity Read ↗

Ligand-independent actions of the orphan receptors/corepressors DAX-1 and SHP in metabolism, reproduction and diseaseSemantic proximity Read ↗

DAX-1, an "antitestis" gene.Semantic proximity Read ↗

Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP HeterodimersSemantic proximity Read ↗

Hypogonadotropic hypogonadism in subjects with DAX1 mutations.Semantic proximity Read ↗

Diverse roles of androgen receptor (AR) domains in AR-mediated signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.