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Article

Targeting SP1 Transcription Factor in Prostate Cancer Therapy

8 Aug 2011

Abstract excerpt

Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences within gene promoter regions. Specificity protein (Sp) family transcription factors play a critical role in various cellular processes and have been shown to be associated with tumorigenesis. The Sp family consists of several members that contain a highly conserved DNA-binding domain composed of three zinc...

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PMID: 22022994
DOI: 10.2174/157340611796799203

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