Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes

16 May 2008

Abstract excerpt

Androgen antagonists or androgen deprivation are the primary therapeutic modalities for the treatment of prostate cancer. Invariably, however, the disease becomes progressive and unresponsive to androgen ablation therapy (hormone refractory). The molecular mechanisms by which androgen antagonists inhibit prostate cancer proliferation are not fully defined. In this study, we identify two molecules which are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostate Cancer Treatment and Research

Source

Identifiers

PMID: 18487222
DOI: 10.1093/carcin/bgn117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genesPMID 18487222Read ↗

Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate CancerSemantic proximity Read ↗

Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen ReceptorSemantic proximity Read ↗

Targeting the BAF complex in advanced prostate cancer.Semantic proximity Read ↗

Androgen Receptor Overexpression in Prostate Cancer Linked to Purα Loss from a Novel Repressor ComplexSemantic proximity Read ↗

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate CancerSemantic proximity Read ↗

The tumor suppressor ING1b is a novel corepressor for the androgen receptor and induces cellular senescence in prostate cancer cellsSemantic proximity Read ↗

ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genesSemantic proximity Read ↗

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signalingSemantic proximity Read ↗

BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancerSemantic proximity Read ↗

Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cellsSemantic proximity Read ↗

BRG1 loss in MiaPaCa2 cells induces an altered cellular morphology and disruption in the organization of the actin cytoskeletonSemantic proximity Read ↗

Androgen Deprivation Increases p300 Expression in Prostate Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.