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Article

INI1-Deficient Tumors

1 Oct 2011

Abstract excerpt

Significant progress has been made in understanding the molecular genetic alterations involved in sarcomagenesis. Cytogenetic and molecular studies have identified nonrandom genetic abnormalities, including tumor suppressor gene inactivation. Mutations, deletions, and other somatic alterations in the tumor suppressor gene INI1 (hSNF5; SMARCB1), which encodes a subunit of the SWI/SNF chromatin remodeling complex,...

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PMID: 21934399
DOI: 10.1097/pas.0b013e31822b325b

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