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SMARCB1/INI1-deficient tumors of adulthood

9 Dec 2020

Abstract excerpt

The SMARCB1/INI1 gene was first discovered in the mid-1990s, and since then it has been revealed that loss of function mutations in this gene result in aggressive rhabdoid tumors. Recently, the term “rhabdoid tumor” has become synonymous with decreased SMARCB1/INI1 expression. When genetic aberrations in the SMARCB1/INI1 gene occur, the result can cause complete loss of expression, decreased expression, and...

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PMID: 33796273
DOI: 10.12688/f1000research.24808.2

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