Article

SMARCB1/INI1-deficient tumors of adulthood

2020-06-30

Abstract excerpt

The SMARCB1/INI1 gene was first discovered in the mid-1990’s, and since then it has been revealed that loss of function mutations in this gene result in aggressive rhabdoid tumors. Recently, the term “rhabdoid tumor” has become synonymous with decreased SMARCB1/INI1 expression. When genetic aberrations in the SMARCB1/INI1 gene occur, the result can cause reduced, complete loss, and mosaic expression. Although SMAR...

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Literature Corpus work: d69f75a5-3842-55a2-837a-d332ab7be3e5
DOI: 10.12688/f1000research.24808.1

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