Article
Genomic and Immunologic Characterization of INI1-Deficient Pediatric Cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2020
Forrest Suzanne J, Al-Ibraheemi Alyaa, Doan Duong, Ward Abigail, Clinton Catherine M, Putra Juan, Pinches R Seth, Kadoch Cigall, Chi Susan N, DuBois Steven G, Leavey Patrick J, LeBoeuf Nicole R, Mullen Elizabeth, Collins Natalie, Church Alanna J, Janeway Katherine A
Abstract excerpt
PURPOSE: Several aggressive pediatric cancers harbor alterations in SMARCB1, including rhabdoid tumors, epithelioid sarcoma, and chordoma. As tumor profiling has become more routine in clinical care, we investigated the relationship between SMARCB1 genetic variants identified by next-generation sequencing (NGS) and INI1 protein expression. Therapeutic approaches for INI1-deficient tumors are limited. Early...
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