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Article

Catechol-O-methyltransferase (COMT) gene variants and pain in chronic pancreatitis.

The Netherlands journal of medicine - 1 Jan 2000

van Esch A A J, de Vries E, Te Morsche R H M, van Oijen M G H, Jansen J B M J, Drenth J P H

Abstract excerpt

BACKGROUND: Pain is the major symptom of chronic pancreatitis. The role of genetics in pancreatic pain is unclear. Catechol-O-methyltransferase (COMT) regulates enkephalin levels and influences pain perception. The COMT gene contains functional polymorphisms that have been found to influence human pain perception. The aim of our study was to investigate COMT single-nucleotide polymorphisms (SNP s) and diplotypes...

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Source

Identifiers

PMID: 21934178

Genes

COMT

Variants

rs6269
rs4633
rs4818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Catechol-O-methyltransferase (COMT) gene variants and pain in chronic pancreatitis.PMID 21934178Read ↗

COMT genetic variants and pain.Semantic proximity Read ↗

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Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis.Semantic proximity Read ↗

Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis.Semantic proximity Read ↗

Are catechol-O-methyltransferase gene polymorphisms genetic markers for pain sensitivity after all? - A review and meta-analysis.Semantic proximity Read ↗

COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis.Semantic proximity Read ↗

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Analysis of catechol-O-methyltransferase gene mutation and identification of new pathogenic gene for paroxysmal kinesigenic dyskinesia.Semantic proximity Read ↗

No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain.Semantic proximity Read ↗

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Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.Semantic proximity Read ↗

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