Article
Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women.
Breast cancer research : BCR - 1 Jan 2007
Foulkes William D, Ghadirian Parviz, Akbari Mohammed Reza, Hamel Nancy, Giroux Sylvie, Sabbaghian Nelly, Darnel Andrew, Royer Robert, Poll Aletta, Fafard Eve, Robidoux André, Martin Ginette, Bismar Tarek A, Tischkowitz Marc, Rousseau Francois, Narod Steven A
Abstract excerpt
BACKGROUND: PALB2 has recently been identified as a breast cancer susceptibility gene. PALB2 mutations are rare causes of hereditary breast cancer but may be important in countries such as Finland where a founder mutation is present. We sought to estimate the contribution of PALB2 mutations to the burden of breast cancer in French Canadians from Quebec. METHODS: We screened all coding exons of PALB2 in a sample...
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