Article
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
Molecular psychiatry - 1 Oct 2012
Lips E S, Cornelisse L N, Toonen R F, Min J L, Hultman C M, Holmans P A, O'Donovan M C, Purcell S M, Smit A B, Verhage M, Sullivan P F, Visscher P M, Posthuma D
Abstract excerpt
Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 cases and 4965 healthy controls, using functional gene group analysis. Identifying groups of genes...
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