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Article

Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.

Schizophrenia research - 1 Feb 2011

Sun Jingchun, Wan Chunling, Jia Peilin, Fanous Ayman H, Kendler Kenneth S, Riley Brien P, Zhao Zhongming

Abstract excerpt

Recently, we prioritized 160 schizophrenia candidate genes (SZGenes) by integrating multiple lines of evidence and subsequently identified twenty-four pathways in which these 160 genes are overrepresented. Among them, four neurotransmitter-related pathways were top ranked. In this study, we extended our previous pathway analysis by applying a systems biology approach to identifying candidate genes for...

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Source

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Identifiers

PMID: 21195589
DOI: 10.1016/j.schres.2010.12.002
PMCID: PMC3031722

Genes

GRB2
HSPA5
YWHAG
YWHAZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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