Article
Activation of the TSG-6 gene by NF-IL6 requires two adjacent NF-IL6 binding sites.
The Journal of biological chemistry - 24 Feb 1995
Klampfer L, Chen-Kiang S, Vilcek J
Abstract excerpt
Tumor necrosis factor (TNF)-stimulated gene 6 (TSG-6) encodes a protein expressed during inflammation. We have previously shown that transcription factors of the NF-IL6 and AP-1 families cooperatively modulate activation of the TSG-6 gene by TNF or interleukin 1 (IL-1) through a promoter region t...
Topics
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cell Adhesion Molecules
- Cells, Cultured
- DNA-Binding Proteins
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Promoter Regions, Genetic
- Protein Binding
- Transcription Factors