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Article

Hypoxia-inducible factor-1α expression and gemcitabine chemotherapy for pancreatic cancer.

Oncology reports - 1 Dec 2011

Kasuya Kazuhiko, Tsuchida Akihiko, Nagakawa Yuichi, Suzuki Minako, Abe Yuta, Itoi Takao, Serizawa Hiromi, Nagao Toshitaka, Shimazu Motohide, Aoki Tatsuya

Abstract excerpt

The normal pancreas has an abundant blood flow, in contrast to pancreatic cancer, which is a hypovascular tumor. During hypoxia under a hypovascular environment, the transcription factor hypoxia-inducible factor-1α (HIF-1α) is activated. High HIF-1α expression reduces sensitivity to gemcitabine (...

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Source

Identifiers

PMID: 21922147
DOI: 10.3892/or.2011.1457

Genes

GEM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21922147-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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